What does low platelet count and high MPV mean? Diabetes and obesity are associated with higher MPV. A high MPV is often due to an underlying medical condition.
What are the symptoms of low platelets?. What happens when your platelets are high?. What is the most common cause of high platelet count?. Should I worry about a slightly elevated platelet count?. What is MPV in blood test during pregnancy?. What should I eat if my platelets are high?. What autoimmune disease causes high platelets?. What is the alarming level of platelets?. What is high MPV with normal platelet count?. What does low platelet count and high MPV mean?. Aleksandra Korniluk, Olga Martyna Koper-Lenkiewicz, Joanna Kamińska, Halina Kemona, Violetta Dymicka-Piekarska, “Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions”, Mediators of Inflammation, vol. 2019. Besides, a higher MPV value might also be indicative of other forms of diseases like heart diseases, hypothyroidism, stroke, or high blood pressure. Since the increased value of MPV correlates with platelet activation, it might also be a possible cause of some forms of cancer which results in platelet activation. A higher value of MPV thus might indicate that older platelets are being destroyed, which is why more platelets are being produced in the bone marrow. New and young platelets are mostly larger and recently released from the bone marrow, whereas the older ones are smaller and circulate through the bloodstream. If the value of MPV is high and the total platelet count is low, it indicates that the bone marrow is rapidly producing platelets. It should be accompanied by the total platelet count. 
However, the result of the MPV test cannot be interpreted alone. This indicates that the average size of the platelets is larger than the average. An MPV value is considered higher than normal when the value is above 12 fl. Thus, an interpretation should only be made once all the CBC test is performed. Depending on the lifestyle of an individual, a low or high MPV value might still be completely normal. In various pathological conditions, the physiological proportion between MPV and platelet count is disturbed, which helps in the diagnosis of some such pathological conditions. Based on the inverse relationship between MPV and the total platelet count, a reduction in their mean volume is accompanied by increased production of platelets. Abnormal results are not necessarily considered indications of severe health issues however, in some cases, these might be significant, so it is important to rule them out. In the case of results with higher or lower values of MPV, further investigations may be warranted. Abnormally high or low values might indicate different forms of diseases or disorders present in the body of the particular individual. The average or normal value of MPV in humans remains at about 7.5 to 12 fl. The normal value of MPV ranges between 7.5 to 12 fl (femtolitre), whereas the percentage of large platelets usually amount to 0.2-5.0% of the whole platelet population. The results of MPV tests might not mean much on their own, but the result interpretation should only be made with the context of other CBC tests. The test is closely related to the platelet count test that measures the total number of platelets present in the blood sample. MPV test is not performed as a diagnostic test for certain diseases instead, the test is performed as an overall general body check-up process. MPV test is essential as the average size of platelets is larger when the body is producing large amounts of platelets, which, in turn, provides inferences regarding platelet formation and destruction. MPV blood test is performed as a part of the Complete Blood Count (CBC) which is a comprehensive test for the complete analysis of blood. The mean platelet volume (MPV) is the measurement of the dimension of platelets, calculated by hematological analyzers depending on the volume distribution during routine blood morphology test. 
Platelets are important blood cells that are responsible for blood clotting, a process that controls blood loss after an injury. MPV (Mean Platelet Volume) test is a test performed to determine the average size of platelets present in a blood sample.
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